How To Repair P53 Gene
Review
. 2016 May 2;half-dozen(5):a026070.
doi: ten.1101/cshperspect.a026070.
p53 in the Deoxyribonucleic acid-Damage-Repair Process
Affiliations
- PMID: 27048304
- PMCID: PMC4852800
- DOI: ten.1101/cshperspect.a026070
Gratis PMC article
Review
p53 in the Dna-Damage-Repair Process
Common cold Spring Harb Perspect Med. .
Free PMC article
Abstract
The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the Deoxyribonucleic acid tin can atomic number 82 to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer evolution. As a central tumor suppressor, p53 guards the genome past orchestrating a variety of Deoxyribonucleic acid-damage-response (DDR) mechanisms. Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role equally a facilitator of Dna repair by halting the cell cycle to permit time for the repair machineries to restore genome stability. In addition, p53 took on various roles to as well directly bear upon the activity of various Dna-repair systems. It thus appears as if p53 is multitasking in providing protection from cancer development by maintaining genome stability.
Copyright © 2016 Common cold Spring Harbor Laboratory Press; all rights reserved.
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Source: https://pubmed.ncbi.nlm.nih.gov/27048304/
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